Noncanonical Roles of Voltage-Gated Sodium Channels
نویسندگان
چکیده
منابع مشابه
Noncanonical Roles of Voltage-Gated Sodium Channels
The Hodgkin-Huxley formulation, at its 60th anniversary, remains a bastion of neuroscience. Sodium channels Nav1.1-Nav1.3 and Nav1.6-Nav1.9 support electrogenesis in neurons and are often considered "neuronal," whereas Nav1.4 and Nav1.5 drive electrogenesis in skeletal and cardiac muscle. These channels are, however, expressed in cell types that are not considered electrically excitable. Here, ...
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A variety of different isoforms of mammalian voltage-gated sodium channels have been identified. These channels can be classified into three different types. Eight type 1 isoforms have been identified in the CNS, PNS, skeletal muscle, and heart. All of these channels have been expressed in exogenous systems, and all of the genes have been mapped. Three type 2 isoforms have been identified in he...
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ژورنال
عنوان ژورنال: Neuron
سال: 2013
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2013.09.012